The objective of the Top Ten Trials session is to provide a multidisciplinary audience with a snapshot of the two most influential trials from each discipline within the past year. The selected trials will generally address important areas of cardiology and may influence clinical practice and inform future clinical guidelines. Usual format is a general presentation of the finding of the study by the Trial Presenter and then a deep dive of the data and relevance of that study by the Trial Discussant. The discussant in each discipline is asked to critically appraise the trials in the context of existing evidence. The discussant should also inform the audience how the trials might change perspective within the discipline or influence wider clinical practice. Chairs Prof. Andrew Clark Dr. Rosita Zakeri Presenter/Discussant Trial Presenter 1: Dr. Beth Banks - SUBCUT-HF II: RCT of SUBCUTaneous furosemide to support early discharge in patients admitted to hospital due to Heart Failure Trial Discussant 1: Dr. Joe Cuthbert - SUBCUT-HF II: RCT of SUBCUTaneous furosemide to support early discharge in patients admitted to hospital due to Heart Failure Trial Presenter 2: Dr. Stephen Rankin - CHIP-BCIS 3: Left Ventricular Unloading in High-Risk Percutaneous Coronary Intervention Trial Discussant 2: Dr. Jennifer Rossington - CHIP-BCIS 3: Left Ventricular Unloading in High-Risk Percutaneous Coronary Intervention Trial Presenter 3: Dr. Mahvash Zaman - Frailty and long-term outcomes in younger patients with acute myocardial infarction Trial Discussant 3: Dr. Cara Hendry - Frailty and long-term outcomes in younger patients with acute myocardial infarction Trial Presenter 4: Dr. Chris Orsborne - TRICORDER: Triple cardiovascular disease detection with an artificial intelligence-enabled stethoscope Trial Discussant 4: Dr. Freya Lodge - TRICORDER: Triple cardiovascular disease detection with an artificial intelligence-enabled stethoscope Trial Presenter 5: Dr. Pok Tin Tang - Cardiac amyloidosis detection from a single echocardiographic video clip: a novel artificial intelligence-based screening tool Trial Discussant 5: Dr. Shawn Morais - Cardiac amyloidosis detection from a single echocardiographic video clip: a novel artificial intelligence-based screening tool